bsm-54277R-Biotin

DATASHEET

Host: Rabbit

Target Protein: Alpha Synuclein

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 6622

Swiss Prot: P37840

Source: Recombinant full length Human protein

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100µL

Concentration: 1mg/ml

Applications: WB(WB(1:1000-2000))
IHC-P(IHC-P(1:200-800))
IHC-F(IHC-F(1:200-800))

Predicted Molecular Weight: 16

Cross Reactive Species: Human
Rat

For research use only. Not intended for diagnostic or therapeutic use.