bsm-54335R-Biotin

DATASHEET

Host: Rabbit

Target Protein: CD46

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 4179

Swiss Prot: P15529

Source: Synthetic peptide within human CD46 aa 50-100

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100µL

Concentration: Lot Dependent

Applications: WB(WB(1:500-2000))
IHC-P(IHC-P(1:100-500))
IHC-F(IHC-F(1:100-500))

Predicted Molecular Weight: 55

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.