bsm-54462R-FITC

DATASHEET

Host: Rabbit

Target Protein: MARK3

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 4140

Swiss Prot: P27448

Source: Recombinant protein within human Mark3 aa 600-750.

Purification: purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1.

Conjugation: FITC

Excitation/ Emission: 494nm/518nm

Size: 100ul

Concentration: Lot Dependent

Applications: WB(1:500-2000)
FCM(1:50-100)

Predicted Molecular Weight: 84

Cross Reactive Species: Human

Predicted Cross Reactive Species: Mouse

For research use only. Not intended for diagnostic or therapeutic use.