bsm-54514R

DATASHEET

Host: Rabbit

Target Protein: Phospho-PAK1(S144)+PAK2(S141)+PAK3(S139)

Modification Site: Ser144+Ser139+Ser141

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 5063

Swiss Prot: O75914

Source: Synthetic phospho-Peptide corresponding to residues surrounding Ser144 of human PAK1.

Purification: purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Size: 100ul

Concentration: Lot Dependent

Applications: WB(1:300-5000)
IF(ICC)(1:50-200)
IP(1-2ug)
IHC(1:50-200)
FCM(1:20-100)
IHC-P(1:200-400)

Predicted Molecular Weight: 65

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.