bsm-54575R

DATASHEET

Host: Rabbit

Target Protein: Phospho-Chk1 (S296)

Modification Site: Ser296

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 1111

Swiss Prot: O14757

Source: Synthetic phospho-Peptide corresponding to residues surrounding Ser296 of human Chk1

Purification: purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2011].

Size: 100ul

Concentration: Lot Dependent

Applications: WB(1:300-5000)
IHC(1:50-200)
IHC-P(1:200-400)

Predicted Molecular Weight: 54

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.