bsm-54629R

DATASHEET

Host: Rabbit

Target Protein: Phospho-SHIP(Y1020)

Modification Site: Tyr1020

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 3635

Swiss Prot: Q92835

Source: Synthetic phospho-Peptide corresponding to residues surrounding Tyr1020 of human SHIP.

Purification: purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.

Size: 100ul

Concentration: Lot Dependent

Applications: WB(1:300-5000)
IF(ICC)(1:50-200)
IP(1-2ug)

Predicted Molecular Weight: 133

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.