bsm-54724R

DATASHEET

Host: Rabbit

Target Protein: Estrogen Receptor alpha

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 2099

Swiss Prot: P03372

Source: Synthetic Peptide within N-terminal Human Estrogen Receptor alpha.

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

The estrogen receptor (ER) is a 66 kDa protein that mediates the actions of estrogens in estrogen responsive tissues. It is a member of a large superfamily of nuclear hormone receptors that function as ligand activated transcription factors. The ER gene consists of more than 140 kb of genomic DNA divided into 8 exons. These translate into a protein with six functionally discrete domains, labeled A through F. A second form of the estrogen receptor, ER beta has recently been described. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti estrogen (e.g. tamoxifen) therapy.

Size: 100ul

Concentration: 1ug/ul

Predicted Molecular Weight: 66

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.