bsm-60018R-PE

DATASHEET

Host: Rabbit

Target Protein: GP1BA

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 2811

Swiss Prot: P07359

Source: KLH conjugated synthetic peptide derived from human CD42b

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq, Mar 2010].

Conjugation: PE

Excitation/ Emission: 496,564nm/578nm

Size: 100µL

Concentration: Lot Dependent

Applications: IF(IHC-P)(IF(IHC-P)(1:100-500))

Predicted Molecular Weight: 67

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.