bsm-60020R

DATASHEET

Host: Rabbit

Target Protein: ERBB2/HER2

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 2064

Swiss Prot: P04626

Source: KLH conjugated synthetic peptide derived from human ERBB2/HER2

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

Size: 100µL

Concentration: Lot Dependent

Applications: IHC-P=1:200-1000

Predicted Molecular Weight: 185

Predicted Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.