DATASHEET
Host:
Rabbit
Target Protein:
CD35
Clonality:
Recombinant
Isotype:
IgG
Entrez Gene:
1378
Swiss Prot:
P17927
Source:
KLH conjugated synthetic peptide derived from human CD35
Purification:
Purified by Protein A.
Storage Buffer:
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.
Conjugation:
AbBy Fluor-488
Excitation/ Emission:
499nm/519nm
Size:
100µL
Concentration:
Lot dependent
Applications:
IF(IHC-P)(IF(IHC-P)(1:100-500))
274
Human
For research use only. Not intended for diagnostic or therapeutic use.