bsm-60779R-Cy7

DATASHEET

Host: Rabbit

Target Protein: Granzyme B

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 3002

Swiss Prot: P10144

Source: KLH conjugated synthetic peptide derived from human GZMB

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

Conjugation: Cy7

Excitation/ Emission: 743nm/767nm

Size: 100µL

Concentration: Lot dependent

Applications: WB(WB(1:500-2000))
IF(IHC-P)(IF(IHC-P)(1:50-200))

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.