bsm-60803R-PerCP-Cy7

DATASHEET

Host: Rabbit

Target Protein: Estrogen receptor alpha

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 2099

Swiss Prot: P03372

Source: KLH conjugated synthetic peptide derived from human ER-Alpha

Purification: purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER Alpha and ER Beta. ER Alpha and ER Beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.

Conjugation: PerCP-Cy7

Excitation/ Emission: 482nm/780nm

Size: 100µl

Concentration: Lot Dependent

Applications: IHC-F
IF(IHC-P)
IHC-P
FCM

Predicted Molecular Weight: 66

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.