bsm-60935R-BF680

DATASHEET

Host: Rabbit

Target Protein: KEAP1

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 9817

Swiss Prot: Q14145

Source: KLH conjugated synthetic peptide derived from human KEAP1

Purification: purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Conjugation: AbBy Fluor-680

Excitation/ Emission: 679nm/702nm

Size: 100µl

Concentration: 1mg/ml

Applications: WB(1:500-2000)
IHC-F(1:100-500)
IF(1:100-500)
IHC-P(1:100-500)

Predicted Molecular Weight: 69

Cross Reactive Species: Human
Mouse
Monkey

For research use only. Not intended for diagnostic or therapeutic use.