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Host: Rabbit
Target Protein: CD31
Clonality: Recombinant
Isotype: IgG
Entrez Gene: 5175
Swiss Prot: P16284
Source: KLH conjugated synthetic peptide derived from human CD31
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage: Store at -20°C for 12 months.
Background:
Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308).
Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684).
Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302).
Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308).
Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892).
Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892).
Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896).
Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896).
Induces susceptibility to atherosclerosis (By similarity).
Conjugation: Biotin
Excitation/ Emission: N/A
Size: 100µL
Concentration: Lot dependent
Applications:
WB(1:200-500)
IHC-P(1:200-500)
IHC-F(1:200-500)
Predicted Molecular Weight: 78
Cross Reactive Species: Human
For research use only. Not intended for diagnostic or therapeutic use.