bsm-61196R-BF488

DATASHEET

Host: Rabbit

Target Protein: beta Arrestin 1

Modification Site: Ser412

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 408

Swiss Prot: P49407

Source: KLH conjugated synthetic peptide derived from human beta Arrestin 1 around the phosphorylation site of S412

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation.

Conjugation: AbBy Fluor-488

Excitation/ Emission: 499nm/519nm

Size: 100ul

Concentration: Lot dependent

Applications: WB(1:300-5000)

Predicted Molecular Weight: 47

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.