bsm-61581R-PerCP-Cy7

DATASHEET

Host: Rabbit

Target Protein: PHD2

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 54583

Swiss Prot: Q9GZT9

Source: KLH conjugated synthetic peptide derived from human PHD2

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF1B. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.

Conjugation: PerCP-Cy7

Excitation/ Emission: 482nm/780nm

Size: 100µL

Concentration: Lot dependent

Applications: WB(1:300-5000)
IP(1-2ug)

Predicted Molecular Weight: 46

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.