bsm-61954R [Primary Antibody]
CD112 Recombinant Antibody
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Host: Rabbit

Target Protein: CD112

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 5819

Swiss Prot: Q92692

Source: KLH conjugated synthetic peptide derived from human Nectin 2

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive.

Size: 100uL

Concentration: Lot dependent

Applications: WB(1:300-5000)
IP(1-2ug)
Flow-Cyt(1ug/Test)
ICC/IF(1:50-100)

Predicted Molecular Weight: 58


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

25 ug total protein per lane of various lysates (see on figure) probed with NECTIN2 | CD112/PVRL2 monoclonal antibody, unconjugated (bsm-61954R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.