bsm-62185R [Primary Antibody]
TRIM29 Recombinant Antibody
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Host: Rabbit

Target Protein: TRIM29

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 23650

Swiss Prot: Q14134

Source: KLH conjugated synthetic peptide derived from human TRIM29

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.

Size: 100µL

Concentration: Lot dependent

Predicted Molecular Weight: 66


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

25 ug total protein per lane of various lysates (see on figure) probed with TRIM29 monoclonal antibody, unconjugated (bsm-62185R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.