bsm-62258R [Primary Antibody]
Phospho-GSK3 A/B (Tyr279/Tyr216) Recombinant Antibody
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Host: Rabbit

Target Protein: GSK3 A/B

Modification Site: Tyr279/Tyr216

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 2931

Swiss Prot: P49840

Source: KLH conjugated synthetic peptide derived from human GSK3 alpha around the phosphorylation site of Y279

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

GSK3A a proline-directed protein kinase of the GSK family. Implicated in the control of several regulatory proteins including glycogen synthase, Myb, and c-Jun. GSK3 and GSK3 have similar functions. GSK3 phophorylates tau, the principal component of neurofibrillary tangles in Alzheimer disease and is required for maximal production of amyloid plaque peptides by secretase.

Size: 100µL

Concentration: Lot dependent

Predicted Molecular Weight: 51,47


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Western blot analysis of 293 cell lysate treated with AP. Using Phospho-GSK3 A/B (Tyr279/Tyr216) (bsm-62258R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.