bsm-62560R [Primary Antibody]
ABRAXAS1 Recombinant Antibody
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Host: Rabbit

Target Protein: ABRAXAS1

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 84142

Swiss Prot: Q6UWZ7

Source: KLH conjugated synthetic peptide derived from human ABRAXAS1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs.

Size: 100ul

Concentration: Lot dependent

Predicted Molecular Weight: 47


Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

25 ug total protein per lane of various lysates (see on figure) probed with ABRAXAS1 monoclonal antibody, unconjugated (bsm-62560R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.