bsm-63027R [Primary Antibody]
MEK5 Recombinant Antibody
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Host: Rabbit

Target Protein: MEK5

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 5607

Swiss Prot: Q13163

Source: KLH conjugated synthetic peptide derived from human MEK5

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM.

Size: 100µL

Concentration: Lot dependent

Applications: WB(1:300-5000)
ICC/IF(1:50-100)

Predicted Molecular Weight: 50


Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Western blot analysis of Hela cell lysate. Using MEK5 (bsm-63027R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.