bsm-70137M

DATASHEET

Host: Mouse

Target Protein: Ki-67

Specificity: Specific for endogenous levels of the ~345 & 395 kDa Ki-67 isoforms. Additional bands are thought to be breakdown products of these 2 isoforms.

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 4288

Swiss Prot: P46013

Source: Recombinant construct containing the N-terminal 300 amino acids of the human sequence expressed in and purified from E. coli.

Purification: Purified by Protein G.

Storage Buffer: PBS + 50% glycerol and 5 mm NaN3

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Ki-67 is a nuclear protein that is considered to be essential for cellular proliferation since it is expressed only in active phases of the cell cycle (G1, S, G2 and mitosis) but not in resting phase G0 (Scholzen & Gerdes 2000). Ki-67 antibodies have therefore been widely used as markers of cell growth. Ki-67 has further been identified as a predicative and prognostic marker in breast, lung, cervical and other cancers (Yerushalmi et al., 2010; Folescu et al., 2018; Das et al., 2018).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 345-395

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.