bsm-70286M

DATASHEET

Host: Mouse

Target Protein: Thyroid Hormone Receptor, α1/α2-Isotype

Specificity: Specific for endogenous levels of the ~50 kDa TR-α1 and the ~58 kDa TR-α2 proteins.

Clonality: Monoclonal

Isotype: IgG2a

Entrez Gene: 7067

Swiss Prot: P10827

Source: Synthetic peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, α1/α2-isotype, conjugated to keyhole limpet hemocyanin (KLH).

Purification: Purified by Protein G.

Storage Buffer: 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

Size: 100ul

Concentration: Lot Dependent

Predicted Molecular Weight: 50/58

Cross Reactive Species: Human
Rat

Predicted Cross Reactive Species: Mouse
Dog
Non-Human Primate

For research use only. Not intended for diagnostic or therapeutic use.