bsm-70326M

DATASHEET

Host: Mouse

Target Protein: Adiponectin (C-terminal region)

Specificity: This antibody detects a 30 kDa* protein on SDS-PAGE immunoblots of human and mouse whole antiserum, as well as detects full length human and mouse recombinant proteins. This sequence has high homology with similar regions in rat and human adiponectin.

Clonality: Monoclonal

Isotype: IgG1

Swiss Prot: Q60994

Source: Clone (M577) was generated from a recombinant protein that included amino acid residues within the C-terminal region of mouse adiponectin.

Purification: Purified by Protein G.

Storage Buffer: PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

Storage: Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Background:

Adiponectin is an adipokine that is secreted primarily from adipocytes and functions in glucose regulation and lipid metabolism. It has also been shown to play a major role in energy homeostasis. Studies report adiponectin secretion in bone, mammary glands, salivary glands, and cardiac tissue in limited quantities. It forms a homo-oligomeric structure and is homologous to complement factor C1q, collagen type VIII, and collagen type X. In humans and mice with low adiponectin levels, increased obesity and insulin resistance is observed. Adiponectin, typically an anti-inflammatory agent, has been shown to exert pro-inflammatory effects in nonmetabolic disease such as irritable bowel syndrome. Low levels of adiponectin in blood have been correlated with higher incidence and poorer prognosis in several cancers, including breast cancer.